Method #2: Update Video Drivers to Fix Outlook Stuck at Loading Profile Screen Verify that the issue is resolved or not.
Close Registry Editor and launch Outlook on the system. Type 1 in the box of Value data and click OK. Perform right-click on DisableHardwareAcceleration and select Modify under the Details pane. Next, enter DisableHardwareAcceleration and hit the Enter key. Click on Edit menu, go to New and select DWORD Value. HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\Common\Graphics\ 
Find and then select the below-mentioned registry subkey. Then, select regedit.exe from the resultant results. After that, type regedit in the text box. In Windows 8, navigate the mouse to top-right corner on Windows and click Search. Afterward, select regedit.exe from the results. In Windows 7, click on the Windows Start button and type regedit in the search bar. In this, we put the DisableHardwareAcceleration registry subkey with the help of following instructions. It is a temporary workaround that can be preferred to fix Outlook hangs loading profile screen issue. So, let’s check out each method in a detailed manner. Generally, there are two workarounds through which this technical error can be repaired in the MS Outlook application. Techniques to Resolve Outlook Stuck at Loading Profile Screen Issue Note:- The same issue also happens in Microsoft Outlook 2013 installation that does not have SP1 configuration. It might be possible that your Outlook data file is corrupted which causes this error. It could be possible that hardware graphics acceleration option, which is managed by the Operating system is not marked as selected for Outlook options. 
One card should belong to NVIDIA and the rest one must be of Intel(R) HD Graphics 4000 card. Users must have minimum two graphics card integrated with the system.It might be possible that users have the Click-to-Run version of Office installed. When users have Microsoft Office 2013 SP1 installed as a Windows Installer-based (MSI) installation.This situation can appear in Microsoft Outlook when any of the below situations are true. So, they can prevent the Outlook in future with Outlook 2010 hangs on the splash screen loading profile issue. Users must know the real cause of this technical error. Reason Behind Outlook Hangs Loading Profile Screen
If you are facing this issue currently and cannot access the Outlook properly, then here we explain the real cause and remedies to this problem. This technical error is very common and can be seen in Microsoft Outlook 2007 to Outlook 365.
Many users have been reported that when they launch Outlook on Windows 10, there Outlook stuck at loading profile screen.
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